OXIS International

OXIS International, Inc. is engaged in the research, development and
sale of products that counteract the harmful effects of “oxidative
stress.”

Oxidative stress refers to the situations in which the body’s
antioxidant and other defensive abilities to combat free radicals (a.k.a
highly reactive species of oxygen and nitrogen) are overwhelmed and
one’s normal healthy balance is either lost or severely compromised.

There products include therapeutic nutraceutical products,
cosmeceutical products and proprietary formulations and clinical
products

that are developed internally and/or out-licensed to biotech and
pharmaceutical companies as drug candidates.

They focus on naturally occurring protective substances since they are
more likely to be both safe and efficacious. Our primary products
incorporate and emphasize the multifaceted “super antioxidant” compound,
L-­Ergothioneine (“ERGO”), as a key component. We own several patents
and pending applications related to ERGO that cover current and planned
products relevant to our nutraceutical and cosmecuetical businesses. Our
patents and patent applications address ERGO’s protective effects and
activities and the ERGO manufacturing process.